Publications
Publications
Baskaran, Sulochanadevi, Lars-Anders Carlson, Goran Stjepanovic, Lindsey N. Young, Do Jin Kim, Patricia Grob, Robin E. Stanley, Eva Nogales, and James H. Hurley. 2014. “Architecture and Dynamics of the Autophagic Phosphatidylinositol 3-Kinase Complex.” eLife 3 (December). https://doi.org/10.7554/eLife.05115.
Chang, Chunmei, Lindsey N. Young, and James H. Hurley. 2019. “The BARA Necessities of PtdIns 3-Kinase Activation in Autophagy.” Autophagy 15 (6): 1122–23. https://doi.org/10.1080/15548627.2019.1596501.
Chang, Chunmei, Lindsey N. Young, Kyle L. Morris, Sören von Bülow, Johannes Schöneberg, Hitomi Yamamoto-Imoto, Yukako Oe, et al. 2019. “Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics.” Molecular Cell 73 (2): 339–53.e6. https://doi.org/10.1016/j.molcel.2018.10.035.
Cherwa, James E., Jr, Lindsey N. Young, and Bentley A. Fane. 2011. “Uncoupling the Functions of a Multifunctional Protein: The Isolation of a DNA Pilot Protein Mutant That Affects Particle Morphogenesis.” Virology 411 (1): 9–14. https://doi.org/10.1016/j.virol.2010.12.026.
Hurley, James H., and Lindsey N. Young. 2017. “Mechanisms of Autophagy Initiation.” Annual Review of Biochemistry 86 (June):225–44. https://doi.org/10.1146/annurev-biochem-061516-044820.
Lawrence, Rosalie E., Simon A. Fromm, Yangxue Fu, Adam L. Yokom, Do Jin Kim, Ashley M. Thelen, Lindsey N. Young, et al. 2019. “Structural Mechanism of a Rag GTPase Activation Checkpoint by the Lysosomal Folliculin Complex.” Science 366 (6468): 971–77. https://doi.org/10.1126/science.aax0364.
Sun, Lei, Lindsey N. Young, Xinzheng Zhang, Sergei P. Boudko, Andrei Fokine, Erica Zbornik, Aaron P. Roznowski, Ian J. Molineux, Michael G. Rossmann, and Bentley A. Fane. 2014. “Icosahedral Bacteriophage ΦX174 Forms a Tail for DNA Transport during Infection.” Nature 505 (7483): 432–35. https://doi.org/10.1038/nature12816.
Tapia, Hugo, Lindsey Young, Douglas Fox, Carolyn R. Bertozzi, and Douglas Koshland. 2015. “Increasing Intracellular Trehalose Is Sufficient to Confer Desiccation Tolerance to Saccharomyces Cerevisiae.” Proceedings of the National Academy of Sciences of the United States of America 112 (19): 6122–27. https://doi.org/10.1073/pnas.1506415112.
Young, Lindsey N., Kelvin Cho, Rosalie Lawrence, Roberto Zoncu, and James H. Hurley. 2016. “Dynamics and Architecture of the NRBF2-Containing Phosphatidylinositol 3-Kinase Complex I of Autophagy.” Proceedings of the National Academy of Sciences of the United States of America 113 (29): 8224–29. https://doi.org/10.1073/pnas.1603650113.
Young, Lindsey N., Felix Goerdeler, and James H. Hurley. 2019. “Structural Pathway for Allosteric Activation of the Autophagic PI 3-Kinase Complex I.” Proceedings of the National Academy of Sciences of the United States of America 116 (43): 21508–13. https://doi.org/10.1073/pnas.1911612116.
Young Lindsey N., Hockenberry Alyson M., and Fane Bentley A. 2014. “Mutations in the N Terminus of the øX174 DNA Pilot Protein H Confer Defects in Both Assembly and Host Cell Attachment.” Journal of Virology 88 (3): 1787–94. https://doi.org/10.1128/jvi.03227-13.
Young, Lindsey N., and Elizabeth Villa. 2023. “Bringing Structure to Cell Biology with Cryo-Electron Tomography.” Annual Review of Biophysics 52 (May):573–95. https://doi.org/10.1146/annurev-biophys-111622-091327.